CJC 1295 with DAC-complex was the first time developed and produced by Canadian scientists with initial purpose to find way to increase effective half-life period of growth hormone release hormone. The very first clinical studies regarding this research compound took place in the year of 2000. In 2006 a study concerning efficacy and effectiveness as well as safety profile of CJC 1295/DAC was done, it includes two double-blind, randomized, placebo-controlled trials. Due to having DAC-complex this research compound possesses greater binding affinity towards GHRH receptors, which in turn protects that hormone from degradation.

So in one way IGF can actually change your genetic capabilities in terms of muscle tissue and cell count. IGF proliferates and differentiates the number of types of cells present. At a genetic level it has the potential to alter an individual’s capacity to build superior muscle density and size. For best results, inject 50 – 100mcg.s of Long IGF-1 R3 approximately one hour after your workout, ideally in the primary muscle trained in the preceding workout – half going into that muscle on one side of the body, the other half going into the mirror image of that muscle on the other side. You can also effectively inject Long IGF-1 R3 subcutaneously. At this point, adequate protein and carbohydrates need to be ingested because IGF-1 is only going to be effective when there is adequate protein in the body to build new tissue from.

<p>Storage temperature thresholds – Store 35 – 46 degrees Fahrenheit (2 – 8 degrees C) which means you should store the

product in your refrigerator and not in your freezer. Long IGF-1 R3 can be exposed to room temp for up to 3 months. Mix with Bacteriostatic Water.
You will say that this sounds just wonderful. What is the problem, however since there are still some who argue that STH offers nothing to athletes? There are, by all means, several athletes who have tried STH and who were sadly disappointed by its results. However, as with many things in life,

there is a logical explanation or perhaps even more than one: 1. The athlete simply has not taken a sufficient amount of STH regularly and over a long enough period of time. STH is a very expensive compound and an effective dosage is unaffordable by most people. 2. When using STH the body also needs more thyroid hormones,insulin, corticosteroids, gonadotropins, estrogens and what a surprise androgens and anabolics. This is also the reason why STH, when taken alone, is considerably less effective and can only reach its optimum effect by the additive intake of steroids, thyorid hormones, and insulin, in particular. But we must point out in this case that STH has a predominantly anabolic effect.
There are three hormones which are needed at the same time in order to allow for maximum anabolic effect. These are STH, insulin, and an LT-3 thyroid hormone, such as, for example, Cytomel. Only then can the liver produce and release an optimal amount of somatomedin and insulin-like growth factors. This anabolic effect can be further enhanced by taking a substance with an anticatabolic effect. These substances are-everybody should probably know by now-anabolic/androgenic steroids or Clenbuterol. Then a synergetic effect takes place.’Are you still wondering why pro bodybuilders are so incredibly massive but, at the same time, totally ripped while you are not. Most athletes have tried STH during preparation for a competition in that phase when the diet is calorie-reduced.

GHRP-6 causes stimulation of the anterior pituitary gland which ultimately causes an increase in GH release.  Since GHRP-6 acts directly on the feedback loop which signals the inhibition of GH release, when natural GH secretion has been inhibited by long term synthetic use, GHRP-6 can be used to re-stimulate the natural production of GH.   GHRP-6 also affects the central nervous system, by protecting neurons as well as increasing strength in a way very similar to the way certain steroids in the Dihydrotestosterone family do.

Benefits of increased Growth Hormone levels through GHRP-6 stimulation include:  an increase in strength, muscle mass and body fat loss, rejuvenation and strengthening of joints, connective tissue and bone mass. Enhanced GH secretion also leads to the liver secreting more IGF-1 (Insulin-Like

Hexarelin is a non-natural (synthetic) growth hormone (GH)-releasing hexapeptide which belongs to the GHS family. This particular protein has been found to act on both pituitary gland and the hypothalamus, however, its mechanisms of action in the human physiologic system has not yet been fully elucidated  (Arvat et al. 1995). This synthetic peptide has similar GH-secreting properties with its predecessors such as the GHRP-6, GHRP-2 and GHRP-1. Hexarelin is GHRP analog in which the Trp was substituted with chemically more table 2-Methyl-Trp (Denghenghi et al. 1994). The chemical structure of which is shown in the following: Many studies on mice have been carried out geared towards deeper understanding of its chemical activity. Many studies reported that some of its effects are increase in muscle strength and endurance, gain muscle mass, neural protection, rehabilitation of the joints and increased rate of wound healing. However, unlike GHRP-6, hexarelin does not induce food intake because of its incapability to drastically increase the grehlin levels that are responsible for the feeling of hunger and faster emptying of the gastric system. But the studies of Deghenghi et al. (1994) reported that hexarelin possessed similar effectiveness in stimulating the GH release in a long-lasting event and slightly more effective than the GHRP-6. These are supported by a number of studies. Locatelli et al. (1999) reported that hexarelin provides protection and healing especially for the cardiac dysfunction and abnormalities. They have observed that 7 days after the administration of the hexarelin to the rat, it prevented the exacerbation of the ischemia-reperfusion damage that has been induced by hypophysectomy. Furthermore, hexarelin also prevented the increase in diastolic pressure of the left ventricular end, so as with coronary perfusion pressure, reactivity of the coronary vasculature to angiotensin and release of the creatine kinase from the perfusate of the heart. Also, it was suggested that hexarelin prevented the fall in prostacyclin release and enhances recovery of contractility. It has also been noted that its mechanisms of action are not mediated by the growth hormone, but most probably because of the activation of specific receptors in the heart (Locatelli et al. 1999). The same results had been obtained by the investigations of Ghigo et al. (1994) whioch have shown that hexarelin administered through the intravenous route had limited variability, but had been suggested to be dose-dependent. It can then be used and administered to humans for clinical applications. Hexarelin (HEX) is a peptide GH secretagogue with a potent ability to stimulate GH secretion and recently reported cardioprotective actions.

With HGH 176-191, results will usually start to become evident around the four-week mark, after being combined with diet and exercise in a daily routine. The best results will begin to show after a minimum of three months after the initial first injection. When buying HGH 176-191, make sure you are actually getting the real thing. According to UK Peptides, fake versions of HGH 176-191, it is easy for those who are inexperienced with growth hormones to tell the difference between HGH 176-191 and something else that may or may not be similar. If you do not see any changes in your physique after a few weeks of using the HGH 176-191 you obtained, check with a medical specialist to confirm its validity.
When you have determined that you got authentic HGH 176-191, you can begin to administer it. After administering the growth hormone, wait about half an hour before consuming a meal. At this point, the hormone has started to take effect and you are allowed to eat whatever you want, regardless of size or caloric intake.
Just like every other steroid out there, HGH 176-191 has its side effects, even though they are short term and exist only because your body is still getting used to it. HGH 176-191 can lead to a feeling of compulsion to continue, which can be precarious for mental health. Once users stop injecting they may start to see results fade, and for some users this can create a sense of self-image dysphoria creeping in. For this reason, it is important to limit how much you come to depend on the use of this steroid for how you view your own physique.
Two of the mildest side effects that are also the most common are water retention and lethargy. These occur in the early stages of using the drug, as your body is still getting used to it, and they will eventually disappear in time.
As always, staying incredibly hydrated is key while using HGH 176-191. The more hydrated you are, the better your body works at melting fat and building muscle while on this regimen. To pair with HGH Fragment 176-191 and get the most out of it, eating a balanced diet is crucial, as well as getting enough sleep each night.
HGH Fragment 176-191 is one of the most commonly used muscle enhancements in the market and shows results in as little as four weeks. it is usually the first choice for bodybuilders and anyone trying to get in shape.

Hypertrophy is what occurs during weight training and steroid use, it is simply an increase in the size of muscle cells. After puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don’t actually gain more. But with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue, and through weight training and proper nutrition you are able to mature these new cells, in other words make them grow and become stronger.

Hypertrophy is what occurs during weight training and steroid use, it is simply an increase in the size of muscle cells. After puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don’t actually gain more. But with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue, and through weight training and proper nutrition you are able to mature these new cells, in other words make them grow and become stronger.

Storage temperature thresholds – Store 35 – 46 degrees Fahrenheit (2 – 8 degrees C) which means you should store the product in your refrigerator and not in your freezer. Long IGF-1

R3 can be exposed to room temp for up to 3 months. Mix with Bacteriostatic Water.

You will say that this sounds just wonderful. What is the problem, however since there are still some who argue that STH offers nothing to athletes? There are, by all means, several athletes who have tried STH and who were sadly disappointed by its results. However, as with many things in life, there is a logical explanation or perhaps even more than one: 1. The athlete simply has not taken a sufficient amount of STH regularly and over a long enough period of time. STH is a very expensive compound and an effective dosage is unaffordable by most people. 2. When using STH the body also

needs more thyroid hormones,insulin, corticosteroids, gonadotropins, estrogens and what a surprise androgens and anabolics. This is also the reason why STH, when taken alone, is considerably less effective and can only reach its optimum effect by the additive intake of steroids, thyorid hormones, and insulin, in particular. But we must point out in this case that STH has a predominantly anabolic effect.

There are three hormones which are needed at the same time in order to allow for maximum anabolic effect. These are STH, insulin, and an LT-3 thyroid hormone, such as, for example, Cytomel. Only then can the liver produce and release an optimal amount of somatomedin and insulin-like growth factors. This anabolic effect can be further enhanced by taking a substance with an anticatabolic effect. These substances are-everybody should probably know by now-anabolic/androgenic steroids or Clenbuterol. Then a synergetic effect takes place.’Are you still wondering why pro bodybuilders are so incredibly massive but, at the same time, totally ripped while you are not. Most athletes have tried STH during preparation for a competition in that phase when the diet is calorie-reduced.

The Ipamorelin Growth Hormone Releasing Peptide Comparison
Ipamorelin is a 3rd generation GHRP behind GHRP-6 and GHRP-2. Ipamorelin has very similar characteristics of GHRP-2: does not have ghrelin’s lipogenic properties and does not promote hunger. Ipamorelin acts synergistically when applied during a Growth Hormone Releasing Hormone (GHRH) pulse or when it is administered along with a GHRH or an analog such as Sermorelin or Modified GRF 1-29 (growth releasing factor, aminos 1-29). The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH. On the other hand, Ipamorelin is similar to GHRP-6 because they both release GH at a very similar strength minus the side effects that of GHRP-6. Both GHRP-6 and GHRP-2 cause a release and an increase in cortisol and prolactin levels, however Ipamorelin only selectively releases GH at any dose. Ipamorelin shares similar functionality to Hexarelin and compared to other peptides, it is a much more stable form of ghrelin and has longer half-life periods of at least two hours long and causes secondary effect by making neurons to become excited.

Studies Related to Ipamorelin
Ipamorelin has been shown to be both highly potent and very

selective in vivo and vitro situations, and has also demonstrated good safety and tolerability in human clinical studies. Research has shown that Ipamorelin is growth hormone specific which means that the pituitary hormones such as cortisol are unaffected. In one study, it was found that young female adult rats had increased bone mass due to 12 weeks of treatment with ipamorelin. This peptide compared to other Growth Hormone Releasing Peptides ensures the benefits without having to deal with

possible negative side effects.

MGF was suggested to play a number of physiological roles because the failure in its expression may result to age-related loss of skeletal function. Included in its functions is its ability to become a potent neuroprotective as supported by the study that has shown functional copies of the MGF cDNA to be expressed in a plasmid vector which then protected facial neurons after nerve damage (Dluzniewska et al. 2005). One such failure is called sarcopenia. It would also appear that with regards to age, the young have a better ability to respond to MGF (4), and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.

When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene is released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary mechanism by which the body produces new muscle tissue.
Insulin like growth factor-1 (IGF-1) expression is implicated in myocardial pathophysiology, and two IGF-1 mRNA splice variants have been detected in rodents, IGF-1Ea and mechano-

growth factor (MGF). Recent research has shown that the expression pattern of IGF-1 gene transcripts in rat myocardium from 1 h up to 8 wks after myocardial infarction induced by left anterior descending coronary artery ligation. In addition, we characterized IGF-1 and MGF E peptide action and their respective signaling in H9C2 myocardial-like cells in vitro. IGF-1Ea and MGF expression were significantly increased, both at transcriptional and translational levels, during the late postinfarction period (4 and 8 wks) in infarcted rat myocardium. Measurements of serum IGF-1 levels in infarcted rats were initially decreased (24 h up to 1 wk) but remained unaltered throughout the late experimental phase (4 to 8 wks) compared with sham-operated rats. Furthermore, specific antia€“IGF-1R neutralizing antibody failed to block the synthetic MGF E peptide action, whereas it completely blocked IGF-1 action on the proliferation of H9C2 cells. Moreover, this synthetic MGF E peptide did not activate Akt phosphorylation, whereas it activated ERK1/2 in H9C2 rat myocardial cells.
Recent studies have also discovered two clones of the hybridonoma secreting monoclonal antibodies to the mechano-growth factor have been developed by cell fusion technique. The monoclonal antibody of one clone recognizes the human MGF peptide that is absent in insulin-like growth factor-1 (IGF-1) which comprised mostly of amino acids from 87-111. Enzyme-linked immunosorbent assay (ELISA) has further shown that there is a high affinity binding constants with the full length of the MGF and the 87-111 fragments of the clones. These can then be used for the quantitation of the MGF through sandwich type assay (Kravchenko et al. 2006).

       Growth hormone–releasing hormone
GHRH is 44 amino-acids polypeptide that stimulates the secretion of growth hormone from the adenohypophysis. It is also called somatocrinin or somatoliberin. It is produced in the cell bodies of periventricular arcuate neurons, and thereafter transported to the neurosecretory terminals of the neurons where they are released. The arcuate neurons do form part of the hypothalamo-hypophyseal portal system. Their release from the neurosecretory terminals occur in a pulsatile fashion and it thus follows that growth hormone (GH) release also occurs in a corresponding pulsatile fashion. GHRH binds to a secretin-type G-protein coupled serpentine receptor called the GHRH-

receptor (GHRHR). Binding causes the receptor to activate both the cAMP (cyclic Adenosine Monophosphate)-dependent pathway and the phospholipase C (PLC) pathway. The terminal downstream actions of the cAMP-dependent pathway do upregulate the transcription of both the GH and GHRHR genes

thereby providing a positive feedback loop that amplifies the production of GH. The GH produced is thereafter packaged in secretory vesicles. The downstream actions of the PLC pathway results in both Na+-voltage-dependent and Ca2+-dependent fusion of the secretory vesicles with the plasma membrane thereby releasing GH into the bloodstream.
The actions of GH ensure an optimal well-regulated post-natal growth. GH also promotes efficient energy metabolism. Studies have also shown that GHRH directly promotes slow wave NREM (non-rapid eye movement) sleep, and thus GHRH insufficiency causes a reduction in the amount and intensity of slow wave NREM sleep which results in either insomnia or dysomnia (sleep disorders that causes sleep to lose its restorative capacity). Studies have also shown that GHRH inhibits the actions of somatostatin. Somatostatin is a polypeptide hormone that inhibits GH secretion from the adenohypophysis. Both GHRH and somatostatin are produced in the same neuron but they are released in alternation to each other thereby resulting in the pulsatile release of GH from the neuron.
Recent research has also shown that GHRH is also produced outside the hypothalamus by pancreatic cells, gastrointestinal tract epithelial cells and in some neoplastic cells. Clinical studies have also shown that the actions of Sermorelin are similar to the GHRH actions. Thus, Sermorelin has been used to diagnose deficiencies in GH secretions. Also, Sermorelin has been investigated for its therapeutic properties as the studies discussed below show.
 

This hormone is used clinically to treat children’s growth disorders and adult growth hormone deficiency. In recent years, replacement therapies with human growth hormones (HGH) have become popular in the battle against aging. Reported effects include decreased body fat, increased muscle mass, increased bone density, increased energy levels, improved skin tone and texture, and improved immune system function. At this time HGH is still considered a very complex hormone and many of its functions are still unknown.

Uses that are controversial include:
GH treatment for remission of Multiple sclerosis
GH treatment to reverse effects of aging in older adults
GH treatment to enhance weight loss in obesity
GH treatment for fibromyalgia
GH treatment for Crohn’s disease and ulcerative colitis
GH treatment for idiopathic short stature
GH treatment for those suffering from burns
GH treatment for bodybuilding or athletic enhancement.
Half-hearted attempts are condemned to failure Minimum effective dosages seem to start at 4 I.U. per day. For comparison: the hypophysis of a healthy; adult, releases 0.5-1.5 I.U. growth hormones daily.
STH is taken over a prolonged period, from at least six weeks to several months. It is interesting to note that the effect of STH does not stop after a few weeks; this usually allows for continued improvements at a steady dosage. It is recommended, in this case, that the athlete eats a complete meal every three hours, resulting in 6-7 meals day. so that the blood sugar level does not fall too low. check the blood sugar level and urine periodically.

The most common problems with STH occur when the athlete intends to inject insulin in addition to STH. The substance somatropin is available as a dried powder and before injecting it must be mixed with the enclosed solution-containing ampule. The ready solution must be injected immediately or stored in the refrigerator for up to 24 hours. It is usually recommended that the compound be stored in the refrigerator. With the exception of the remedy Saizen the biological activity of growth hormones is usually not impaired when storing the dry substance at 15-25 ℃(room temperature); however, a cooler place (2-8 ℃) is preferable. On the black market the price for 4 I.U. each of the compounds Genotropin, Humatrope, Norditropin, and Saizen, in Europpe is $80-120 for a prick-through vial including  the solution ampule. As already mentioned, there are many fakes. It is noted that for the U.S.-American growth hormonescompounds, the substance content is not given in I.U.(International Units) but in mg (milligrams).

Since l mg corresponds to exactly 2.7 I.U. the 5mg solution of the compound Humatrope by Lilly contains exactl 13.5 I.U. of Somatropin. The 10 mg solution of the Protropin compound by the Genentech therefore contains 27 I.U. of Somatropin. In American powerlifting and bodybuilding circles Humatrope is usually preferred over Protropin. The reason is that Humatrope is synthesized from a chain of 191 amino acids and thus is identical to the amino acid sequence of the human growth hormones. Protropin, on the other hand, consists of 192.